BDBM50065258 (2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol::(2S,3R,4S,5R)-2-methylpiperidine-3,4,5-triol::CHEMBL314772::Fucosidase Inhibitor, 3
SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
InChI Key InChIKey=VYOCYWDJTQRZLC-KCDKBNATSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50065258
TargetTissue alpha-L-fucosidase(Bos taurus)
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Ki value against bovine alpha-L-fucosidaseMore data for this Ligand-Target Pair
TargetTissue alpha-L-fucosidase(Bos taurus)
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase by para-nitrophenolate release assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.20nMAssay Description:Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine epididymis; Competitive Inhibition typeMore data for this Ligand-Target Pair
Affinity DataKi: 6.20nMAssay Description:Compound was tested for inhibitory activity (competitive) against alpha-L-fucosidase from bovine kidneyMore data for this Ligand-Target Pair
Affinity DataKi: 6.20nMAssay Description:Tested for inhibitory activity against alpha-L-fucosidase from bovine epididymus (sigma)More data for this Ligand-Target Pair
Affinity DataKi: 9.80nMAssay Description:Tested for inhibitory activity against alpha-L-fucosidase from solubilised human neutrophilsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human liver alpha-L-fucosidaseMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Inhibition constant against Alpha-FucosidaseMore data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Binding affinity against alpha-L-fucosidase in bovine kidney was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibitory activity measured against alpha-L-fucosidase of bovine epididymis by colorimetric assay using the D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
TargetTissue alpha-L-fucosidase(Bos taurus)
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of rat epididymis alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair
TargetTissue alpha-L-fucosidase(Bos taurus)
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of bovine alpha-L-fucosidaseMore data for this Ligand-Target Pair
Affinity DataKd: 372nMpH: 8.5 T: 2°CAssay Description:The kinetic studies involving a spectrophotometric product were conducted by monitoring the change in UV/visible absorbance with a Cintra 10 spectrop...More data for this Ligand-Target Pair
Affinity DataKd: 55.1nMpH: 7.0 T: 2°CAssay Description:The kinetic studies involving a spectrophotometric product were conducted by monitoring the change in UV/visible absorbance with a Cintra 10 spectrop...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of placental alpha-L-fucosidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 14.8nMpH: 6.0 T: 2°CAssay Description:The kinetic studies involving a spectrophotometric product were conducted by monitoring the change in UV/visible absorbance with a Cintra 10 spectrop...More data for this Ligand-Target Pair
Affinity DataKd: 27nMpH: 6.5 T: 2°CAssay Description:The kinetic studies involving a spectrophotometric product were conducted by monitoring the change in UV/visible absorbance with a Cintra 10 spectrop...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 4 hits for monomerid = 50065258
ITC DataΔG°: -10.7kcal/mole −TΔS°: 0.0530kcal/mole ΔH°: -10.2kcal/mole
pH: 6.0 T: -236.15°C
pH: 6.0 T: -236.15°C
ITC DataΔG°: -10.0kcal/mole −TΔS°: -0.513kcal/mole ΔH°: -14.7kcal/mole
pH: 6.5 T: -236.15°C
pH: 6.5 T: -236.15°C
ITC DataΔG°: -10.0kcal/mole −TΔS°: -0.680kcal/mole ΔH°: -15.6kcal/mole
pH: 6.5 T: -236.15°C
pH: 6.5 T: -236.15°C
ITC DataΔG°: -8.84kcal/mole −TΔS°: -0.566kcal/mole ΔH°: -13.4kcal/mole
pH: 6.5 T: -236.15°C
pH: 6.5 T: -236.15°C