BDBM50065315 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one::CHEMBL86921

SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1

InChI Key InChIKey=TUNFCKFZFPSXAU-VBKFSLOCSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50065315   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataKi:  155nMAssay Description:Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataKi:  508nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataKi:  618nMAssay Description:Displacement of Thio-T from human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataIC50:  2.26E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065315(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed