BDBM50076141 (S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid::2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid::CHEMBL27449

SMILES CC(C)C[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1cccc2ccccc12)C(O)=O

InChI Key InChIKey=PKMVDYSKPDHRLR-KOSHJBKYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50076141   

LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  55nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  203nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  200nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  54nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  50nMAssay Description:Inhibition of GGTase1 isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed