BDBM50081173 CHEMBL3421972

SMILES COc1cc(OC2CCN(C)CC2)ccc1Nc1nccc(n1)-c1c[nH]c2cnccc12

InChI Key InChIKey=FTZQWKAIKYEWPM-UHFFFAOYSA-N

Data  3 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50081173   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50081173(CHEMBL3421972)
Affinity DataIC50:  20nMAssay Description:Inhibition of human wild-type TTK (514 to 795) expressed in insect sf9 cellsMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50081173(CHEMBL3421972)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged IGF-1R using fluorescence substrate after 80 mins by caliper off-chip incubation mobility shif...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50081173(CHEMBL3421972)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant Dyrk1B (unknown origin) using FITC-Asp-His-Thr-Gly-Phe-Leu-Thr-Glu-Tyr-Val-Ala-Thr-Arg-NH2 as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed