BDBM50081537 CHEMBL3422092

SMILES [H][C@]12CC[C@@]([H])(CC(O)C1)N2c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H](C1CC1)c1ccccn1

InChI Key

Data  1 KI  15 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50081537   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataKi:  0.700nMAssay Description:Competitive inhibition of amino terminal GST-fused full length human TTK using His6-SUMO-TTK-N as substrate by Lineweaver-Burk plot analysis in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of amino terminal GST-fused full length human TTK using His6-SUMO-TTK-N as substrate preincubated for 15 mins prior to ATP addition by ind...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Ret V804L mutant by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  280nMAssay Description:Inhibition of human Ret V804M mutant by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human Ret by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  68nMAssay Description:Inhibition of human JNK3 by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  320nMAssay Description:Inhibition of human MAPK1 by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  160nMAssay Description:Inhibition of human MELK by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  690nMAssay Description:Inhibition of human MuSK by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  130nMAssay Description:Inhibition of PLK4 (unknown origin) by indirect ELISA detection systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataEC50:  14nMAssay Description:Inhibition of TTK (unknown origin) transfected in human HCT116 cells after 4 hrs by near infrared imager analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataEC50: >6.00E+3nMAssay Description:Inhibition of AURKA (unknown origin) transfected in human HCT116 cells after 4 hrs by near infrared imager analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant AURKA (unknown origin) preincubated for 15 mins prior to ATP addition by FRET-based homogenous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human CYP3A4 using BFC as substrate preincubated for 10 mins followed by enzyme/substrate addition measured after 30 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human CYP3A4 using BFC as substrate preincubated for 10 mins followed by enzyme/substrate addition measured after 30 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of amino terminal GST-fused full length human TTK using His6-SUMO-TTK-N as substrate preincubated for 15 mins prior to ATP addition by ind...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50:  490nMAssay Description:Inhibition of human cKit V560G mutant by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human cKit by millipore radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed