BDBM50085044 (S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid::(S)-2-(2-benzoylphenylamino)-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid::2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID::2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid(GI 262570)::CHEMBL107367::Farglitazar

SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1

InChI Key InChIKey=ZZCHHVUQYRMYLW-HKBQPEDESA-N

Data  10 KI  4 IC50  27 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 50085044   

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...Checked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human Peroxisome proliferator activated receptor gamma using scintillation proximity assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  490nMAssay Description:Maximal reporter activity against human Peroxisome proliferator activated receptor alpha Gal4 chimeric in transiently transfected CV-1 cells by funct...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  490nMAssay Description:Tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinityto bind to human Peroxisome proliferator activated receptor delta using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  6.07E+3nMAssay Description:The compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor deltaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  6.31E+3nMAssay Description:The compound was tested in vitro for inhibiting the 50% binding of Peroxisome proliferator activated receptor alphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataKi:  1.11E+8nMAssay Description:Agonist activity at PPARgammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  321nMAssay Description:Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataIC50:  2.87E+3nMAssay Description:Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  6nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of Src-1 by HTRF assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  3nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PBP by HTRF assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  5nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of CBP1-453 by HTRF assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  4nMAssay Description:Partial agonist activity at human PPARgamma LBD assessed as activation of PGC1 by HTRF assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  345nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  5nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataIC50:  1.22E+3nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataIC50:  25nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.339nMAssay Description:Transactivation of PPARgamma assessed as induction of alkaline phosphatase activityMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  1.40nMAssay Description:Transactivation of human Gal4-fused PPARgamma LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  122nMAssay Description:Transactivation of human Gal4-fused PPARalpha LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.339nMAssay Description:Tested functionally in vitro for inducing 50% of the maximum alkaline phosphate activity (Transactivation) against Peroxisome proliferator activated ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  457nMAssay Description:In vitro transactivation of Peroxisome proliferator activated receptor alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  1.5nMAssay Description:Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferat...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.339nMAssay Description:in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator a...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  1.5nMAssay Description:-log concentration required to induce 50% maximum lipogenic activity against Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.339nMAssay Description:Transactivation of Homo sapiens (human) PPARgamma assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataIC50:  217nMAssay Description:Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.350nMAssay Description:Agonist activity for murine PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity for Human PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  450nMAssay Description:Agonist activity for Human PPAR alpha receptor in transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxo Wellcome Research & Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.350nMAssay Description:Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against murine Peroxisome p...Checked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.340nMAssay Description:Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection as...Checked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  1.5nMAssay Description:Ability to promote differentiation of C3H10T1/2 stem cells to adipocytes using lipogenesis assay mediated through activation of Peroxisome proliferat...Checked by AuthorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  457nMAssay Description:Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against human Peroxisome pr...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  457nMAssay Description:Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  450nMAssay Description:Maximal reporter activity against human Peroxisome proliferator activated receptor alpha Gal4 chimeric in transiently transfected CV-1 cells by funct...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50085044((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Affinity DataEC50:  0.340nMAssay Description:Maximal reporter activity against human Peroxisome proliferator activated receptor gamma Gal4 chimeric in transiently transfected CV-1 cells by funct...More data for this Ligand-Target Pair