BDBM50087691 8-(4-Isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL166387

SMILES CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key InChIKey=AYIPPDCLGFAXBJ-KDURUIRLSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50087691   

TargetNociceptin receptor(RAT)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087691(8-(4-Isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-s...)
Affinity DataKi:  0.0790nMAssay Description:Inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087691(8-(4-Isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-s...)
Affinity DataKi:  3.20nMAssay Description:Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087691(8-(4-Isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-s...)
Affinity DataKi:  26nMAssay Description:Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087691(8-(4-Isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-s...)
Affinity DataKi:  242nMAssay Description:Inhibition against binding of radioligand [Ile5,6-3H]-deltorphin to membrane from baby hamster kidney cells infected with forest virus encoding the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(RAT)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087691(8-(4-Isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-s...)
Affinity DataEC50:  38nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed