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BDBM50093753 (2S,3S)-2-Amino-3-benzyloxy-succinic acid::(2S,3S)-2-amino-3-(benzyloxy)succinic acid::(3S)-3-(BENZYLOXY)-L-ASPARTIC ACID::CHEMBL79140::DL-TBOA

SMILES: N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O

InChI Key: InChIKey=BYOBCYXURWDEDS-IUCAKERBSA-N

Data: 3 KI  29 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50093753   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA3


(RAT)
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Suntory Institute for Bioorganic Research

Curated by PDSP Ki Database




Mol Pharmacol 53: 195-201 (1998)


Article DOI: 10.1124/mol.53.2.195
BindingDB Entry DOI: 10.7270/Q2RF5SJH
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 8.17E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.61E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 6.40E+4n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 6.37E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.64E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.21E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.34E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of [14C]glutamate uptake at human EAAT3 expressed in african green monkey COS1 cells


Bioorg Med Chem 16: 7740-8 (2008)


Article DOI: 10.1016/j.bmc.2008.07.001
BindingDB Entry DOI: 10.7270/Q2TM79XR
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 960n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 955n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 3.72E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 4


(Rattus norvegicus)
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.29E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.09E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.91E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 4


(Rattus norvegicus)
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method


J Med Chem 61: 7741-7753 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00700
BindingDB Entry DOI: 10.7270/Q2G44ST4
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


J Med Chem 53: 7236-50 (2010)


Article DOI: 10.1021/jm100959g
BindingDB Entry DOI: 10.7270/Q27081NR
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


J Med Chem 53: 7236-50 (2010)


Article DOI: 10.1021/jm100959g
BindingDB Entry DOI: 10.7270/Q27081NR
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair