BDBM50106497 6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline-5,8-dione::6-chloro-7-(2-morpholinoethylamino)quinoline-5,8-dione::CHEMBL337173::NSC-663284
SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12
InChI Key InChIKey=DWRQCWWWWDTWHB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50106497
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataKi: 29nMAssay Description:Inhibition of human Cdc25AMore data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataKi: 89nMAssay Description:Inhibition of human Cdc25CMore data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataKi: 95nMAssay Description:Inhibition of human Cdc25BMore data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibitory activity against recombinant CDC25CMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory Activity against Recombinant Human PTP1More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory Activity against Recombinant Human VHRMore data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of recombinant human Cdc25A using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a...More data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human Cdc25C using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a...More data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of recombinant human Cdc25B using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Max Planck Institute Of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair