BDBM50111591 4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benzene-1,2-diol::CHEMBL34034

SMILES Oc1ccc(cc1O)-c1csc(Nc2ccc(F)cc2F)n1

InChI Key InChIKey=GFUKFZXSGYDXIF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50111591   

TargetBeta-galactosidase(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of Beta-galactosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibitory activity against cloned Dihydrofolate reductase (cDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against Amp C beta-LactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against chymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase(Thermus thermophilus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against malate dehydrogenase (MDH) from Thermus flavusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against Chymotrypsinogen from Thermus flavusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50111591(4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benz...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed