BDBM50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490
SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O
InChI Key InChIKey=UAHFGYDRQSXQEB-BVMGHOOCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 72 hits for monomerid = 50121900
Affinity DataKi: 0.560nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.570nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.630nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.630nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.630nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.820nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human wild type MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Homo sapiens (Human))
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center & Research Institute
Curated by ChEMBL
Affinity DataKi: 9.90nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of Eu-NDP-alphaMSH from human MC4 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Functional activity at the mouse melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Functional activity at the mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.320nMAssay Description:Functional activity at the mouse melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0860nMAssay Description:Functional activity at the mouse melanocortin 5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-4 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-5 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 0.0980nMAssay Description:Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0380nMAssay Description:Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0380nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-1 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 0.0980nMAssay Description:In vitro activaction of mouse recombinant Melanocortin-3 receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.0980nMAssay Description:Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.0380nMAssay Description:Agonist activity to the mouse Melanocortin-1 receptor (mMC1R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Agonist activity to the mouse Melanocortin-4 receptor (mMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.0980nMAssay Description:Effective concentration against mouse Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.22nMAssay Description:Inhibitory concentration towards melanocortin MC4 receptor by displacing radioligand [125I]-NDP-MSH; ND = not determinedMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Effective concentration against mouse Melanocortin 5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.380nMAssay Description:Effective concentration against mouse Melanocortin 1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Effective concentration against mouse melanocortin MC4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.160nMAssay Description:Effective concentration for mouse Melanocortin-4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0180nMAssay Description:Effective concentration for mouse Melanocortin-1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0890nMAssay Description:Effective concentration for mouse Melanocortin-3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0950nMAssay Description:Effective concentration for mouse Melanocortin-5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:In vitro agonist potency for Mouse Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0320nMAssay Description:In vitro agonist potency for Mouse Melanocortin 1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0780nMAssay Description:In vitro agonist potency for Mouse Melanocortin 5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0700nMAssay Description:In vitro agonist potency for Mouse Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair