BDBM50124566 (R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine::(S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine::2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine::2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine::2-[2-ethoxyphenoxy(phenyl)methyl]-1,4-oxazinane::CHEMBL14370::REBOXETINE::rac-syn-2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine
SMILES CCOc1ccccc1OC(C1CNCCO1)c1ccccc1
InChI Key InChIKey=CBQGYUDMJHNJBX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50124566
Affinity DataKi: 0.690nMAssay Description:Displacement of [3H]-dopamine from rat cerebral cortex NET after 7 minsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:In vitro binding affinity of the compound was determined against human norepinephrin transporter in human embryonic kidney cell line by using [3H]-ni...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibition of [3H]Nisoxetine uptake in human noradrenaline transporter transfected HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:Invitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT)More data for this Ligand-Target Pair
Affinity DataKi: 13.7nMAssay Description:Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Invitro competitive binding versus [N-methyl-3H]-WIN 35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)More data for this Ligand-Target Pair
Affinity DataKi: 129nMAssay Description:Inhibition of [125I]-RTI-55 binding to human serotonin transporter expressed in human embryonic kidney cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wayne State University
Curated by ChEMBL
Wayne State University
Curated by ChEMBL
Affinity DataKi: 503nMAssay Description:Inhibition of SERT in rat cerebral cortex assessed as [3H]serotonin accumulationMore data for this Ligand-Target Pair
Affinity DataKi: 1.40E+3nMAssay Description:Inhibition of [3H]Citalopram uptake in human 5HTT transfected HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:In vitro binding affinity of the compound was determined against human dopamine transporter in dog kidney cell line by using [3H]-WIN- 35,428 radioli...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]WIN-35428 uptake in human DAT transfected HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 242nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR celsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 242nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in MDCK-Net6 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of DA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of [3H]NA reuptake at NA transporter in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 242nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wayne State University
Curated by ChEMBL
Wayne State University
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Binding affinity against serotonin transporter (SERT) by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataIC50: 242nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University
Curated by ChEMBL
Emory University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of [3H]DA reuptake at DA transporter in HEK293 cellsMore data for this Ligand-Target Pair