BDBM50126977 CHEMBL3629591

SMILES Cc1cc(NS(=O)(=O)C2CC2)cc(c1)-c1ccc(s1)C(=O)c1c(F)ccc(O)c1F

InChI Key InChIKey=ARYRCGSUJZWHTF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50126977   

Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50126977(CHEMBL3629591)
Affinity DataIC50:  8nMAssay Description:Inhibition of human placental microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate incubated for 20 mins by HPLC analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstradiol 17-beta-dehydrogenase 2(Mus musculus)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50126977(CHEMBL3629591)
Affinity DataIC50:  55nMAssay Description:Inhibition of mouse liver microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate incubated for 20 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Mus musculus)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50126977(CHEMBL3629591)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant mouse 17beta HSD1 expressed in HEK293 cells using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50126977(CHEMBL3629591)
Affinity DataIC50:  5nMAssay Description:Inhibition of human placental cytosolic 17beta HSD1 using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate incubated for 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed