BDBM50129062 CHEBI:43968::ICI-194660::Meropenem::Merrem::Merrem iv::SM-7338

SMILES [H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)[C@H](C)[C@]12[H]

InChI Key InChIKey=DMJNNHOOLUXYBV-PQTSNVLCSA-N

Data  6 IC50  3 Kd  1 Koff

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50129062   

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Uit The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataKd:  1.20E+4nMAssay Description:Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Uit The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Klebsiella pneumoniae)
Uit The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataKon:  0.346M-1s-1Assay Description:Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Klebsiella pneumoniae)
Uit The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataKd:  850nMAssay Description:Binding affinity to native signal deficient and TEV cleavage site containing His-tagged Klebsiella pneumoniae OXA-48 expressed in Escherichia coli as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidase(Staphylococcus aureus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataIC50:  3.39E+5nMAssay Description:Binding affinity to PBP2a in methicillin-resistant Staphylococcus aureus 123-1 by [14C]benzylpenicillin labelled competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidase(Staphylococcus aureus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataIC50:  1.38E+5nMAssay Description:Binding affinity to PBP2a in methicillin-resistant Staphylococcus aureus 12386-1 by [14C]benzylpenicillin labelled competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50129062(CHEBI:43968 | ICI-194660 | Meropenem | Merrem | Me...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed