BDBM50129574 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-[1,4]benzoquinone::CHEMBL315754

SMILES CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O

InChI Key InChIKey=ZXKWXMBUCWWPDM-UHFFFAOYSA-N

Data  1 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50129574   

TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataKi:  640nMAssay Description:Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  1.50E+4nMAssay Description:Eight point inhibitory concentration against Cell division cycle 25 degree C was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibitory concentration of compound against mutant M531A of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory concentration of compound against mutant E474Q of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory concentration of compound against mutant R544L of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  2.82E+4nMAssay Description:Inhibitory concentration of compound against Cell division cycle 25B was determined using CDK2-p-TpY/Cyclin A as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory concentration of compound against mutant M532A of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory concentration of compound against mutant Y528F of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibitory concentration of compound against truncated mutant of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Eight point inhibitory concentration against Cell division cycle 25A was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  5.60E+3nMAssay Description:Eight point inhibitory concentration against Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibitory concentration of compound against mutant WT of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibitory concentration of compound against mutant E478Q of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory concentration of compound against mutant F475A of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration of compound against mutant R492L of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50129574(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory concentration of compound against mutant R482L of Cell division cycle 25B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed