BDBM50131225 CHEMBL3634769::US9260425, 515

SMILES CCn1cncc(-c2cc3c(n[nH]c3cn2)-c2cccc(n2)N2CCNCC2)c1=O

InChI Key InChIKey=BAUZKJYZGGFFLL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131225   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50131225(CHEMBL3634769 | US9260425, 515)
Affinity DataKi:  0.0150nMpH: 7.2Assay Description:PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genetech

US Patent
LigandPNGBDBM50131225(CHEMBL3634769 | US9260425, 515)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of Pim1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50131225(CHEMBL3634769 | US9260425, 515)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of Pim3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50131225(CHEMBL3634769 | US9260425, 515)
Affinity DataKi:  0.145nMAssay Description:Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed