BDBM50133152 9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylidene]-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL134602

SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/c4ccccc4)c3c12

InChI Key InChIKey=QCRMHUMUIWUQMT-QRVIBDJDSA-N

Data  3 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50133152   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataKi:  207nMAssay Description:Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataEC50:  28nMAssay Description:Agonistic activity against human progesterone receptor in T47D breast cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataEC50:  5.30nMAssay Description:Agonistic activity against human progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133152(9-Fluoro-2,2,4-trimethyl-5-[1-phenyl-meth-(Z)-ylid...)
Affinity DataIC50:  640nMAssay Description:Inihibition of human androgen receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed