BDBM50133231 (R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine::(R)-2-(4-Iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine::(R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine::CHEMBL134519

SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I

InChI Key InChIKey=BGMZUEKZENQUJY-SSDOTTSWSA-N

Data  14 KI  4 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50133231   

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  4nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2A receptor expressed in HEK cells by radioligand completion assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]ketanserin from rat prefrontal cortex 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  10nMAssay Description:Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  18nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  2.29E+3nMAssay Description:Binding affinity for 5-hydroxytryptamine 1 receptor of rat prefrontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  2.29E+3nMAssay Description:Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  2.30E+3nMAssay Description:Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataIC50:  3.84E+3nMAssay Description:In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  20nMAssay Description:Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50: >1.00E+4nMAssay Description:Tested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  17.8nMAssay Description:Agonist activity at 5HT2A receptor in rat A7r5 cells assessed as intracellular calcium mobilization relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  30nMAssay Description:Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataIC50:  0.460nMAssay Description:Displacement of [125I]DOI from 5HT2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  30.2nMAssay Description:Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(RAT)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  11.9nMAssay Description:Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  27.7nMAssay Description:In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(RAT)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataEC50:  12nMAssay Description:Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed