BDBM50136268 (3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxylic acid 3-hydroxyamide 4-{[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide}::CHEMBL423906

SMILES Cc1cc(COc2ccc(NC(=O)[C@H]3CCN(C[C@@H]3C(=O)NO)S(C)(=O)=O)cc2)c2ccccc2n1

InChI Key InChIKey=WWXZQIVISJRIMS-VXKWHMMOSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50136268   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataKi:  306nMAssay Description:Inhibitory activity against matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataKi:  656nMAssay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataKi: >4.95E+3nMAssay Description:Inhibitory activity of the compound against matrix metalloproteinase-1(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136268((3R,4S)-1-Methanesulfonyl-piperidine-3,4-dicarboxy...)
Affinity DataIC50:  0.480nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed