BDBM50142887 1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[3,4-d]pyrimidine::1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine::1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine::4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine::AG-1879::CHEMBL406845::PP2::US10544104, Compound 146::US10688093, Compound PP2 (Pfizer)::US11701353, PP2 (Pfizer)::US9765037, Compound 146::cid_4878
SMILES CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12
InChI Key InChIKey=PBBRWFOVCUAONR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50142887
Affinity DataKi: 500nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Binding affinity to human recombinant Abl by cell free assayMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibitory activity against Src in cell free assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
University Of Dundee
Curated by PDSP Ki Database
University Of Dundee
Curated by PDSP Ki Database
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
University Of Dundee
Curated by PDSP Ki Database
University Of Dundee
Curated by PDSP Ki Database
Affinity DataKi: <1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of His6-tagged c-Src kinase domain using AEEEIYGEFEAKKKK as substrate pre-incubated for 10 mins before substrate addition measured after 3...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of CK1delta in the presence of 20uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of HckChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+7nMAssay Description:Inhibition of JAK2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of p56lck autophosphorylationChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of ZAP70Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of GST-tagged c-Src preincubated for 30 mins measured after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:The ADP-Glo Kinase Assay is specifically designed to quantify kinase activity by measuring the ADP produced in the reaction The reaction buffer...More data for this Ligand-Target Pair
Affinity DataIC50: 36.6nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Src (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of FYN (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36.6nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Korea Institute Of Science & Technology (Kist School)
Curated by ChEMBL
Korea Institute Of Science & Technology (Kist School)
Curated by ChEMBL
Affinity DataIC50: 4.23E+3nMAssay Description:Inhibition of p38 alpha (unknown origin) using Ser/Thr 15 as substrate incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+5nMAssay Description:Inhibition of EPHA3 (unknown origin) assessed as dissociation constant by ELISA-like binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of GST-fussed c-SRC after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of c-Src after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 3.65E+4nMAssay Description:Equilibrium binding constant for EPH receptor B2More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMT: 2°CAssay Description:Kinase activity (Src-family kinases, Hck, Lyn, Fyn, and c-Src) and the effect of the molecules were determined by ProFluor Src-Family Kinase Assay Ki...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
University Of Dundee
Curated by PDSP Ki Database
University Of Dundee
Curated by PDSP Ki Database
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataKd: 296nMAssay Description:Binding affinity to chicken 6-His tagged c-Src expressed in Escherichia coli Bl21 (DE3) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataEC50: 1.29E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
Affinity DataEC50: 4.82E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair