BDBM50153378 CHEMBL3775041::US9630914, Compound 12

SMILES CCCCCCNC(=O)Oc1cccc(c1)-c1ccc(cc1F)C(C)C(O)=O

InChI Key InChIKey=USQOVYLRWBOSQC-UHFFFAOYSA-N

Data  18 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50153378   

TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  31nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  430nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant human COX2 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic aci...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  31nMAssay Description:Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  10nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  12nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  430nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  9.90nMAssay Description:Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  8.60nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  1.30E+4nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  5.40E+4nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  9.40nMAssay Description:Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  9.70nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  0.0100nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  10nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  31nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  12nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153378(CHEMBL3775041 | US9630914, Compound 12)
Affinity DataIC50:  12nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed