BDBM50157570 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-methoxybenzenesulfonamide::CHEMBL3752151::D0O6XT::GTPL8573::NI 57::NI-57::US11773085, Compound B26

SMILES COc1cc(ccc1S(=O)(=O)Nc1ccc2n(C)c(=O)c(C)cc2c1)C#N

InChI Key InChIKey=UEMQPCYDWCSVCU-UHFFFAOYSA-N

Data  10 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50157570   

TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  619nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  114nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  1.01E+3nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Assays were performed as described previously with minor modifications(Philpott et al., 2011). All reagents were diluted in 25 mM HEPES, 100 mM NaCl,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataKd:  31nMAssay Description:Binding affinity to BRPF1B (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9 [133-239](Homo sapiens (Human))
Foghorn Therapeutics

US Patent
LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50: >1.00E+3nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataKd:  410nMAssay Description:Binding affinity to BRPF3 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  4.38E+3nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  47nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataIC50:  315nMAssay Description:Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 1(Homo sapiens (Human))
Oxford University

LigandPNGBDBM50157570(4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-meth...)
Affinity DataKd:  110nMAssay Description:Binding affinity to BRPF2 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed