BDBM50157606 CHEMBL3785432

SMILES CCCS(=O)(=O)c1nc(NC2CC2)cc(n1)-c1ccc2n(ccc2c1)C1CC(C)(C)NC(C)(C)C1

InChI Key InChIKey=XVECNLUKQDKOST-UHFFFAOYSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50157606   

TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataKd:  80nMAssay Description:Binding affinity to CERC2 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataIC50:  47nMAssay Description:Binding affinity to CERC2 (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataKd:  79nMAssay Description:Binding affinity to CECR2 (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra-acetylate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataIC50:  38nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataIC50:  19nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra-acetylate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50157606(CHEMBL3785432)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed