BDBM50157692 CHEMBL1439::CL-307579::Sodium; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::TAZOBACTAM SODIUM::US9035062, TAZ::sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::tazobactum

SMILES C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)O[Na]

InChI Key InChIKey=RFMIKMMOLPNEDG-QVUDESDKSA-M

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50157692   

TargetBeta-lactamase(Escherichia coli)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  950nMpH: 7.0Assay Description:For the measurement of β-lactamase inhibitory activity, 100 μM (final concentration) nitrocefin (Oxoid) was used as a substrate, and 2.5% D...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity of the compound against TEM-1 (class A) beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  4.77E+4nMAssay Description:Inhibitory activity of the compound against AmpC (class C) beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity of the compound against TEM-1 (class A) beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Staphylococcus aureus)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  290nMAssay Description:The compound was evaluated for inhibition against Beta-lactamase TEM derived from Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase L1 type 3(Stenotrophomonas maltophilia)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50: >2.00E+5nMAssay Description:Beta-Lactamase Inhibition of metallo-beta-lactamase representative class B (L1) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  5.32E+4nMAssay Description:Beta-Lactamase inhibitory activity against representativeclass C (P99) serine enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase type 2(Bacillus cereus)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50: >2.00E+5nMAssay Description:Beta-Lactamase Inhibition of metallo-beta-lactamase representative class B (L1) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  4.00E+3nMAssay Description:The concentration of compound to inhibit Beta-lactamase was measured on Enterobacter cloacae SC 12368More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  943nMAssay Description:The concentration of compound to inhibit Beta-lactamase was measured on Enterobacter cloacae P99More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  25nMAssay Description:The concentration of compound to inhibit Beta-lactamase was measured on Escherichia coli WC3310More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  5.19E+4nMAssay Description:Inhibition of Class C beta-lactamase from E. cloacae strain P99More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Staphylococcus aureus)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  320nMAssay Description:Inhibition of class A TEM-1 beta-lactamase derived from Enterobacter cloacaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  4.98E+4nMAssay Description:The compound was evaluated for inhibition against Class C beta-lactamase derived from Enterobacter cloacae P99More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  122nMAssay Description:Beta-Lactamase inhibitory activity against representative class A (TEM-1) serine enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  8.40E+4nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase type 2(Bacteroides fragilis)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibition of Bacteroides fragilis CcrAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Staphylococcus aureus)
Southern Methodist University

Curated by ChEMBL
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  2.57E+3nMAssay Description:The compound was evaluated for inhibition against Beta-lactamase derived from Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Escherichia coli)
Meiji Seika Pharma

US Patent
LigandPNGBDBM50157692(CHEMBL1439 | CL-307579 | Sodium; (2S,3S,5R)-3-meth...)
Affinity DataIC50:  4.77E+4nMAssay Description:Inhibitory activity of the compound against AmpC (class C) beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed