BDBM50157741 CHEMBL374508::E-64::E64
SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7]
InChI Key InChIKey=LTLYEAJONXGNFG-DCAQKATOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 37 hits for monomerid = 50157741
Affinity DataKi: 30nMAssay Description:Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...More data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-2 after 10 minMore data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-2More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.96E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.08E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.03E+4nMAssay Description:Inhibition of Plasmodium falciparum Falcipain-2 after 10 to 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of cathepsin L (unknown origin) using fluorometric Z-Phe-Arg-AMC as substrate by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-aminomethylcoumarin as substrate measured after 5 mins by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 482nMAssay Description:Inhibition of Plasmodium falciparum falcipain 3 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by spectrofluorometryMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of falcipain2More data for this Ligand-Target Pair
TargetCysteine protease falcipain-3 [5-492](Plasmodium falciparum)
University Of Mississippi
Curated by ChEMBL
University Of Mississippi
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of falcipain3More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of human leukocyte elastase using [14C]GS7340 substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of cathepsin L (unknown origin) using Cbz-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of porcine liver carboxylesterase using [14C]GS7340 substrateMore data for this Ligand-Target Pair
TargetCysteine protease falcipain-3 [5-492](Plasmodium falciparum)
University Of Mississippi
Curated by ChEMBL
University Of Mississippi
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-3More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain-2More data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of Carica papaya papain by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of Plasmodium falciparum falcipain-2More data for this Ligand-Target Pair
Affinity DataIC50: 13.7nMAssay Description:Inhibitory activity against Cathepsin B was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15(pREP4) using Cbz-Phe-Arg-AMC as substrate by fluorescen...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Plasmodium falciparum recombinant falcipain 2 expressed in Escherichia coli using Z-Leu-Arg-AMC as substrate incubated for 30 min prior...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of cathepsin B (unknown origin) using Cbz-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of cathepsin B (unknown origin) using fluorometric Z-Phe-Arg-AMC as substrate by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human cathepsin L.More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of recombinant CatA using [14C]GS7340 substrateMore data for this Ligand-Target Pair