BDBM50158688 CHEMBL3752911

SMILES [H][C@@]12CN(c3ccccn3)[C@@]([H])(CN1\C=C\C(=O)c1ccccc1O)C2

InChI Key InChIKey=INAICWLVUAKEPB-QSTFCLMHSA-N

Data  1 IC50  10 Kd

PDB links: 2 PDB IDs match this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50158688   

TargetProtein polybromo-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  48nMAssay Description:Binding affinity to PB1 bromodomain5 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  89nMAssay Description:Binding affinity to SMARCA4 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetProtein polybromo-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd: <100nMAssay Description:Binding affinity to human PB1 isoform 5 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd: <100nMAssay Description:Binding affinity to human SMARCA4 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetProtein polybromo-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  48nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein polybromo-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  5.80E+3nMAssay Description:Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  21nMAssay Description:Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
TargetProbable global transcription activator SNF2L2(Homo sapiens (Human))
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  18nMAssay Description:Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
TargetProtein polybromo-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  25nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  89nMAssay Description:Binding affinity to His6-tagged human recombinant SMARCA4 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microcalorime...More data for this Ligand-Target Pair