BDBM50165699 CHEMBL3797454

SMILES CCC[C@H]1N(CCC[C@@]1(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)Oc1cc(ccn1)C(N)=O)C(=O)c1cnccc1C(F)(F)F

InChI Key InChIKey=UHCAFHQHBCXDJR-ZUKKLESISA-N

Data  1 IC50

PDB links: 7 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50165699   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50165699(CHEMBL3797454)Copy SMILESCopy InChI

Affinity DataIC50:  8.72E+3nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI