BDBM50166588 CHEMBL3798011

SMILES C[C@@H](N1c2cc(ccc2C(=O)NC1(C)C)-n1c2cccnc2[nH]c1=O)c1ccccc1

InChI Key InChIKey=WNYKGJHEQVIFGL-OAHLLOKOSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50166588   

TargetProtein kinase C delta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCdelta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged Aurora-B (unknown origin) preincubated for 5 mins using Aurora substrate peptide as substrate measured after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCalpha (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >100nMAssay Description:Inhibition of N-terminal FLAG-tagged FAK cytoplasmic domain (unknown origin) expressed in baculovirus preincubated for 5 mins measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >100nMAssay Description:Inhibition of full length N-terminal His-tagged recombinant human SRC preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScree...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >100nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human c-Met preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCzeta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged PI3Kalpha (unknown origin) co-expressed with p85alpha in baculovirus using L-alpha-phosphatidyl-D-myo-inositol 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged PLK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using alpha-casein as substrate measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length human CDC7 co-expressed with N-terminal GST-tagged ASK in baculovirus preincubated for 5 mins using MCM2 as substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human ROCK1 expressed in baculovirus preincubated for 5 mins using long S6 peptide as substrate measured after 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged CK1delta (unknown origin) expressed in Escherichia coli preincubated for 5 mins using CK1tide as substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged ASK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using myelin basic protein as substrate m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged CHK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using CHKtide as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged MAPKAPK2 (unknown origin) expressed in baculovirus preincubated for 5 mins using KKLNRTLSVA-NH2 as substrate mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged MEK1 (unknown origin) expressed in freestyle293 system preincubated for 5 mins using GST-tagged ERK1 K71A as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human IRAK4 expressed in baculovirus preincubated for 5 mins using myelin basic protein as substrate measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged ERK1 (unknown origin) expressed in baculovirus preincubated for 5 mins using myelin basic protein as substrate m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged VEGFR2 cytoplasmic domain (unknown origin) expressed in baculovirus preincubated for 5 mins measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >10nMAssay Description:Inhibition of CLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >10nMAssay Description:Inhibition of N-terminal GST-tagged GSK-3beta (unknown origin) expressed in baculovirus preincubated for 5 mins using GSK3 substrate peptide measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >10nMAssay Description:Inhibition of N-terminal GST-tagged human TrkA expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence of ATP by AlphaScr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged human EphA5 catalytic domain expressed in baculovirus preincubated for 5 mins measured after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IRK (unknown origin) preincubated for 5 mins measured after 60 mins in presence of ATP by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of C-terminal 6His-tagged CDK2/N-terminal GST-tagged cyclin A (unknown origin) expressed in baculovirus preincubated for 5 mins using hist...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged p38alpha (unknown origin) expressed in baculovirus preincubated for 5 mins using myelin basic protein as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50:  11nMAssay Description:Inhibition of PKCtheta in human Jurkat cells after overnight incubation by luminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166588(CHEMBL3798011)
Affinity DataIC50: >10nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCbeta (unknown origin) expressed in baculovirus preincubated for 5 mins using fluorescein-PKC substrate measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed