BDBM50174285 3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200513

SMILES CCCCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12

InChI Key InChIKey=HISKJZZJMYSEGO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50174285   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Merck

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against mouse 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Merck

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50174285(3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-...)
Affinity DataIC50:  183nMAssay Description:Inhibitory activity against human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed