BDBM50181532 CHEMBL201307::N-(3-fluorophenyl)-2-(2-(7-(3-(4-(hydroxymethyl)piperidin-1-yl)propoxy)-6-methoxyquinazolin-4-ylamino)thiazol-5-yl)acetamide::N-(3-fluorophenyl)-2-{2-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide::N-3-fluorophenyl)-2-2-7-3-4-hydroxymethyl)piperidin-1-yl)propoxy)-6-methoxyquinazolin-4-ylamino)thiazol-5-yl)acetamide

SMILES COc1cc2c(Nc3ncc(CC(=O)Nc4cccc(F)c4)s3)ncnc2cc1OCCCN1CCC(CO)CC1

InChI Key InChIKey=QNJAKUMXJFWQOG-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50181532   

TargetAurora kinase B(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  7nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Aurora A kinase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against PKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory activity against FGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  800nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against p38-alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory activity against CSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity against IGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against JNK1alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against human hERG receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibitory activity against CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50181532(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Aurora A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed