BDBM50181844 (1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amino-5-chloro-2-methoxybenzoate::CHEMBL201621

SMILES COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12

InChI Key InChIKey=JTBHFVSMJCSNFC-HZMBPMFUSA-N

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50181844   

Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181844((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Affinity DataKi:  0.183nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181844((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181844((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181844((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amin...)
Affinity DataEC50:  1.5nMAssay Description:Agonism at 5HT4 receptor in rat tunica muscularis mucosaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed