BDBM50183803 CHEMBL206968::N-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-5-methyl-N-(4-(methylsulfonyl)phenyl)isoxazole-3-carboxamide

SMILES Cc1cc(no1)C(=O)N(Cc1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=PXYPUNRFIKKXFX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183803   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183803(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183803(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human GST-PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183803(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human GST-PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183803(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183803(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  30nMAssay Description:Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed