BDBM50193786 4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL219049

SMILES CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O

InChI Key InChIKey=OHFPORFQCIWVDI-NFAVILPFSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50193786   

Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193786(4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed