BDBM50195289 1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide::CHEMBL220102

SMILES O[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCCCC1)C(C3)C2

InChI Key InChIKey=CEZQNMXBDYZVET-NIYRFRDPSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195289   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataKi:  2nMAssay Description:Inhibition of human truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as inhibition of cortisol formation by fluorescent polarization immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of mouse 11beta-HSD2 assessed as cortisol disappearance by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195289(1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hy...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of human 11beta-HSD2 assessed as cortisol disappearance by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed