BDBM50195492 3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methylpiperidin-4-yl)benzo[d]oxazol-2(3H)-one::CHEMBL221158

SMILES C[C@@H]1C[C@@H](CCN1C(=O)c1cc(Cl)c(N)c(Cl)c1)n1c2ccccc2oc1=O

InChI Key InChIKey=HXIKSCJQFMRVPJ-DGCLKSJQSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195492   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195492(3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195492(3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methy...)
Affinity DataKi:  140nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195492(3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methy...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells by fluorescence polarization immuno-assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195492(3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50195492(3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed