BDBM50198240 CHEMBL3908487

SMILES OC(=O)C(=O)Nc1ccc2nc(NC(=O)c3cc(Br)c(Br)[nH]3)sc2c1

InChI Key InChIKey=ZDVZBRWEKLWNNU-UHFFFAOYSA-N

Data  5 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50198240   

TargetDNA gyrase subunit B(Staphylococcus aureus)
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50198240(CHEMBL3908487)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50198240(CHEMBL3908487)
Affinity DataIC50:  58nMAssay Description:Inhibition of Escherichia coli DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence of b...More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50198240(CHEMBL3908487)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50198240(CHEMBL3908487)
Affinity DataIC50:  58nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50198240(CHEMBL3908487)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
University Of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50198240(CHEMBL3908487)
Affinity DataKd:  230nMAssay Description:Binding affinity to Escherichia coli DNA gyrase B ATP binding site by surface plasmon resonance assayMore data for this Ligand-Target Pair