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BDBM50216541 CHEMBL613::POA::PYRAZINOIC ACID::PZA::Rifater::pyrazinoicacid

SMILES: OC(=O)c1cnccn1

InChI Key: InChIKey=NIPZZXUFJPQHNH-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50216541   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50216541
PNG
(CHEMBL613 | POA | PYRAZINOIC ACID | PZA | Rifater ...)
Show SMILES OC(=O)c1cnccn1
Show InChI InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
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CHEBI
CHEMBL
MMDB
PC cid
PC sid
PDB
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Article
PubMed
n/an/an/an/a 6.30E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
BindingDB Entry DOI: 10.7270/Q2NP244M
More data for this
Ligand-Target Pair
Sirtuin-6 (SIRT6)


(Homo sapiens (Human))
BDBM50216541
PNG
(CHEMBL613 | POA | PYRAZINOIC ACID | PZA | Rifater ...)
Show SMILES OC(=O)c1cnccn1
Show InChI InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/a 9.27E+5n/an/an/an/an/an/a



University at Albany



Assay Description
Inhibitory constants (Ki) and IC50 values were determined under saturating substrate conditions by using a fluorimetric assay (components were purcha...


Chembiochem 18: 931-940 (2017)


Article DOI: 10.1002/cbic.201600655
BindingDB Entry DOI: 10.7270/Q2CJ8CC2
More data for this
Ligand-Target Pair