BDBM50236025 CHEMBL2016761::US11149049, No. C2

SMILES Nc1ncnn2c(ccc12)[C@@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N

InChI Key InChIKey=DFVPCNAMNAPBCX-LTGWCKQJSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50236025   

TargetDNA-directed RNA polymerase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human mitochondrial RNA polymerase after 30 mins in presence of [33P]GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human DNA polymerase beta preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRous sarcoma virus integrase(Rous sarcoma virus (strain Prague C) (RSV-PrC))
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50:  120nMAssay Description:Standard RSV polymerase assays were conducted in the presence of 3 μL extract of RSV-infected cells in a reaction buffer containing 50 mM tris-a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50:  1.00E+3nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50:  3.60E+3nMAssay Description:The enzyme activity of dengue virus NS5 polymerase domain (DENVpol, serotype 2, New Guinea C strain) was measured as an incorporation of tritiated NM...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Human rhinovirus 16)
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50:  270nMAssay Description:The enzyme activity of hepatitis C virus RNA polymerase (HCVpol) and human rhinovirus 16 RNA polymerase (HRV16pol) is measured as an incorporation of...More data for this Ligand-Target Pair
In DepthDetails US Patent