BDBM50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib
SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
InChI Key InChIKey=HHZIURLSWUIHRB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 564 hits for monomerid = 50237710
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 4.10nMAssay Description:Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 29.3nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 41.9nMAssay Description:Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 15(Mus musculus)
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 79nMAssay Description:Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 99nMAssay Description:Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 223nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 302nMAssay Description:Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 3(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 443nMAssay Description:Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 4(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 446nMAssay Description:Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 6(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 461nMAssay Description:Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetInsulin receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCarbonic anhydrase 13(Mus musculus (mouse))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 4.67E+3nMAssay Description:Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 5.49E+3nMAssay Description:Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetRet proto-oncogene(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
University Of Tampere And Tampere University Hospital
Curated by ChEMBL
Affinity DataKi: 1.49E+4nMAssay Description:Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Genomics Institute Of The Novartis Research Foundation
Curated by PDSP Ki Database
Affinity DataIC50: 120nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
Affinity DataIC50: >700nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School
Massachusetts General Hospital And Harvard Medical School
Affinity DataIC50: 43nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School
Massachusetts General Hospital And Harvard Medical School
Affinity DataIC50: 0.5nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
Affinity DataIC50: 214nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
Affinity DataKd: 1.70E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against phospho...More data for this Ligand-Target Pair
Affinity DataKd: 415nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School
Massachusetts General Hospital And Harvard Medical School
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair