BDBM50239490 CHEMBL4073250::US10329302, Example 122::US11702424, Example 122

SMILES CCOc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O

InChI Key InChIKey=WMLLUHFTFWNDCD-NSHDSACASA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50239490   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50:  672nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50:  24nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50:  24nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50:  24nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed