BDBM50239940 CHEBI:85083::PSI-7977, GS-7977::Sofosbuvir::Sovaldi
SMILES CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1
InChI Key InChIKey=TTZHDVOVKQGIBA-IQWMDFIBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50239940
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human CYP2C9 using sulfaphenazole as substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 230nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human CYP3A4 using ketoconazole as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2 using alpha-naphthoflavone as substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 64nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS5B RNA-dependent-RNA polymerase assessed as reduction in viral replication after 72 hrs by indirect imm...More data for this Ligand-Target Pair
Affinity DataEC50: 3.09E+4nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus infected in African green monkey Vero cells assessed as antiviral activity by DAPI-staining ...More data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus infected in human NPC assessed as antiviral activity by DAPI-staining based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 58nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 61nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 58nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 61nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 64nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 64nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 155nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days b...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 using quinidine as substrateMore data for this Ligand-Target Pair