BDBM50240240 CHEMBL4102132

SMILES Fc1ccc(cc1)C1=CCCN[C@@H]1CNc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1

InChI Key InChIKey=QXJYYBNFOZOHFW-LJQANCHMSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50240240   

TargetCytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  386nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  1.72E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  33nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  31nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed