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BDBM50240386 5-amino-4-oxopentanoic acid::5-aminolevulinic acid::AMINOLEVULINIC ACID::Aminolevulinic Acid Hydrochloride::CHEMBL601::Levulan::delta-aminolevulinic acid

SMILES: NCC(=O)CCC(O)=O

InChI Key: InChIKey=ZGXJTSGNIOSYLO-UHFFFAOYSA-N

Data: 4 KI  1 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50240386   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Oligopeptide transporter, kidney isoform


(Rattus norvegicus)
BDBM50240386
PNG
(5-amino-4-oxopentanoic acid | 5-aminolevulinic aci...)
Show SMILES NCC(=O)CCC(O)=O
Show InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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Article
PubMed
2.30E+5n/an/an/an/an/an/an/an/a



Kyoto University Hospital

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells


Pflugers Arch 440: 679-84 (2000)


Article DOI: 10.1007/s004240000339
BindingDB Entry DOI: 10.7270/Q2CR5X6C
More data for this
Ligand-Target Pair
Oligopeptide transporter small intestine isoform


(Homo sapiens (Human))
BDBM50240386
PNG
(5-amino-4-oxopentanoic acid | 5-aminolevulinic aci...)
Show SMILES NCC(=O)CCC(O)=O
Show InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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Article
PubMed
7.90E+5n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition constant (Ki) for human intestinal peptide carrier


J Med Chem 46: 5725-34 (2003)


Article DOI: 10.1021/jm030976x
BindingDB Entry DOI: 10.7270/Q22N531C
More data for this
Ligand-Target Pair
Xaa-Pro dipeptidase


(Homo sapiens (Human))
BDBM50240386
PNG
(5-amino-4-oxopentanoic acid | 5-aminolevulinic aci...)
Show SMILES NCC(=O)CCC(O)=O
Show InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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9.60E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine kidney prolidase


Bioorg Med Chem Lett 5: 2825-2828 (1995)


Article DOI: 10.1016/0960-894X(95)00494-E
BindingDB Entry DOI: 10.7270/Q2JM29KW
More data for this
Ligand-Target Pair
Solute carrier family 15 member 1


(Rattus norvegicus)
BDBM50240386
PNG
(5-amino-4-oxopentanoic acid | 5-aminolevulinic aci...)
Show SMILES NCC(=O)CCC(O)=O
Show InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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Article
PubMed
2.20E+6n/an/an/an/an/an/an/an/a



Kyoto University Hospital

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells


Pflugers Arch 440: 679-84 (2000)


Article DOI: 10.1007/s004240000339
BindingDB Entry DOI: 10.7270/Q2CR5X6C
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens (Human))
BDBM50240386
PNG
(5-amino-4-oxopentanoic acid | 5-aminolevulinic aci...)
Show SMILES NCC(=O)CCC(O)=O
Show InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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Article
PubMed
n/an/a 1.29E+4n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair