BDBM50240448 2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldiphosphonic acid::CHEMBL34249::[2-(3,4-Dichloro-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid

SMILES OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=PLCHIKRJFFNZDC-UHFFFAOYSA-N

Data  2 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50240448   

TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataKi:  4.40E+3nMAssay Description:Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataKi:  3.80E+4nMAssay Description:Competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-reciprocal ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase E92Q mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase N155H mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase G140S mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50: >5.00E+5nMAssay Description:Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase E138K mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  1.50E+5nMAssay Description:Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol monophosphatase 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  2.30E+4nMAssay Description:Tested for the inhibitory activity against recombinant bovine brain myo-inositol monophosphataseMore data for this Ligand-Target Pair
In DepthDetails Article