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BDBM50241333 4-(benzhydryloxy)-1-methylpiperidine::CHEMBL1492::DIPHENYLPYRALINE

SMILES: CN1CCC(CC1)OC(c1ccccc1)c1ccccc1

InChI Key: InChIKey=OWQUZNMMYNAXSL-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50241333   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(RAT)
BDBM50241333
PNG
(4-(benzhydryloxy)-1-methylpiperidine | CHEMBL1492 ...)
Show SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
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Article
PubMed
3.20n/an/an/an/an/an/an/an/a



TBA

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 75: 6290-4 (1978)


Article DOI: 10.1073/pnas.75.12.6290
BindingDB Entry DOI: 10.7270/Q2FN14P6
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM50241333
PNG
(4-(benzhydryloxy)-1-methylpiperidine | CHEMBL1492 ...)
Show SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
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n/an/a 5.09E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...


Drug Metab Dispos 40: 2332-41 (2012)


Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))
BDBM50241333
PNG
(4-(benzhydryloxy)-1-methylpiperidine | CHEMBL1492 ...)
Show SMILES CN1CCC(CC1)OC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
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PubMed
n/an/a 420n/an/an/an/an/an/a



Wake Forest University Health Sciences

Curated by ChEMBL


Assay Description
Displacement of [125I]RTI-55 dopamine transporter binding in rat striatal membrane


Bioorg Med Chem Lett 15: 4915-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.028
BindingDB Entry DOI: 10.7270/Q2H41S7P
More data for this
Ligand-Target Pair