Found 6 hits for monomerid = 50242401 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
AMP-activated protein kinase, alpha-1 subunit
(Rattus norvegicus) | BDBM50242401
 (4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)Show SMILES Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 Show InChI InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 116 | n/a | n/a | n/a | n/a |
Lund University
Curated by ChEMBL
| Assay Description Activation of rat AMPKalpha1alpha2beta1gamma1 kinase |
J Biol Chem 282: 32549-60 (2007)
Article DOI: 10.1074/jbc.M706536200 BindingDB Entry DOI: 10.7270/Q2BC3ZBQ |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase Complex 1
(Homo sapiens (Human)) | BDBM50242401
 (4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)Show SMILES Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 Show InChI InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PDB Article PubMed
| n/a | n/a | n/a | 487 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity for full length human N-terminal His/BAP-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus by surface pla... |
Bioorg Med Chem Lett 26: 5139-5148 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.065 BindingDB Entry DOI: 10.7270/Q25M67PH |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
5'-AMP-activated protein kinase Complex 1
(Homo sapiens (Human)) | BDBM50242401
 (4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)Show SMILES Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 Show InChI InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Volgograd State Medical University
Curated by ChEMBL
| Assay Description Activation of human AMPK alpha1/beta1/gamma1 expressed in baculovirus/Sf9 cells using SAMS peptide as substrate incubated for 15 mins by in presence ... |
Bioorg Med Chem Lett 29: 2443-2447 (2019)
Article DOI: 10.1016/j.bmcl.2019.07.035 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
5'-AMP-activated protein kinase Complex 1
(Homo sapiens (Human)) | BDBM50242401
 (4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)Show SMILES Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 Show InChI InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) | PDB
Reactome pathway
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| n/a | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta1gamma1 expressed in Escherichia coli BL21 cells after 1 to... |
J Med Chem 59: 2879-93 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01201 BindingDB Entry DOI: 10.7270/Q26976KB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
AMPK alpha1/beta2/gamma1
(Homo sapiens (Human)) | BDBM50242401
 (4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)Show SMILES Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 Show InChI InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) | PDB
Reactome pathway
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| PDB Article PubMed
| n/a | n/a | n/a | 1.45E+4 | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta2gamma1 expressed in Escherichia coli BL21 cells after 1 to... |
J Med Chem 59: 2879-93 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01201 BindingDB Entry DOI: 10.7270/Q26976KB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
AMPK alpha2/beta1/gamma1
(Homo sapiens (Human)) | BDBM50242401
 (4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-di...)Show SMILES Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 Show InChI InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia GoogleScholar
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CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
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| n/a | n/a | n/a | n/a | 390 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human AMPK alpha2/beta1/gamma1 expressed in Escherichia coli BL21 |
J Med Chem 61: 6421-6467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00180 BindingDB Entry DOI: 10.7270/Q2DJ5J62 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |