BDBM50248048 CHEMBL449757::N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-1-yl)propyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide

SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCCN2CCCC2)cn1

InChI Key InChIKey=HBNFTDDTRWSQBS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248048   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248048(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248048(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248048(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248048(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed