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BDBM50251868 (Z)-thiacloprid::CHEMBL451432::{(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide

SMILES: Clc1ccc(CN2CCS\C2=N/C#N)cn1

InChI Key: InChIKey=HOKKPVIRMVDYPB-UVTDQMKNSA-N

Data: 4 KI  8 IC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50251868   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholine receptor subunit beta-like 2


(Drosophila melanogaster)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
MMDB

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PubMed
1.20n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to Drosophila brain nicotinic acetylcholine receptor assessed as [3H]IMI binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Acetylcholine Binding protein


(Aplysia Californica)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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3.90n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to salt water mollusc Aplysia californica AChBP Y55W mutant assessed as [3H]acetamiprid binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetylcholine Binding protein


(Lymnaea stagnalis)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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220n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-4


(Gallus gallus)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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240n/an/an/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Binding affinity to recombinant Gallus gallus (chicken) alpha4beta2 nicotinic acetylcholine receptor assessed as [3H]NIC binding by radioligand bindi...


J Agric Food Chem 59: 2825-8 (2011)


Article DOI: 10.1021/jf1019455
BindingDB Entry DOI: 10.7270/Q2GF0XCJ
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells


J Agric Food Chem 48: 6016-24 (2000)


Article DOI: 10.1021/jf000873c
BindingDB Entry DOI: 10.7270/Q27H1NGG
More data for this
Ligand-Target Pair
Aldehyde oxidase


(Oryctolagus cuniculus)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol


J Agric Food Chem 59: 4860-7 (2011)


Article DOI: 10.1021/jf200485k
BindingDB Entry DOI: 10.7270/Q2QF8WR8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Agaricus bisporus (mushroom) tyrosinase


J Agric Food Chem 59: 4860-7 (2011)


Article DOI: 10.1021/jf200485k
BindingDB Entry DOI: 10.7270/Q2QF8WR8
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4


(Mus musculus)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a 860n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...


J Agric Food Chem 48: 6016-24 (2000)


Article DOI: 10.1021/jf000873c
BindingDB Entry DOI: 10.7270/Q27H1NGG
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon


(Homo sapiens (Human))
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a 1.20E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...


J Agric Food Chem 48: 6016-24 (2000)


Article DOI: 10.1021/jf000873c
BindingDB Entry DOI: 10.7270/Q27H1NGG
More data for this
Ligand-Target Pair
Acetylcholine receptor subunit beta-like 2


(Drosophila melanogaster)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
MMDB

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n/an/a 2.70n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptor


J Agric Food Chem 48: 6016-24 (2000)


Article DOI: 10.1021/jf000873c
BindingDB Entry DOI: 10.7270/Q27H1NGG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4


(Gallus gallus)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a 860n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]nicotine from chick alpha4beta2 nAChR


J Med Chem 51: 4213-8 (2008)


Article DOI: 10.1021/jm800191a
BindingDB Entry DOI: 10.7270/Q2D21XDZ
More data for this
Ligand-Target Pair
Acetylcholine receptor subunit beta-like 2


(Drosophila melanogaster)
BDBM50251868
PNG
((Z)-thiacloprid | CHEMBL451432 | {(2Z)-3-[(6-chlor...)
Show SMILES Clc1ccc(CN2CCS\C2=N/C#N)cn1
Show InChI InChI=1S/C10H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2/b14-10-
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n/an/a 7.5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster head membrane after 90 min by filter binding assay


J Neurochem 75: 1294-303 (2000)


Article DOI: 10.1046/j.1471-4159.2000.751294.x
BindingDB Entry DOI: 10.7270/Q2H134XH
More data for this
Ligand-Target Pair