BDBM50256750 CHEMBL475817::N-(6-amino-5-chloropyridin-3-yl)-2-chloro-5-(3-(trifluoromethyl)benzamido)benzamide

SMILES Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1Cl

InChI Key InChIKey=CJXUHPRULWSPBE-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50256750   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Chk1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PDGFRb (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  478nMAssay Description:Inhibition of PTK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  672nMAssay Description:Inhibition of EphB4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kdr (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Pak1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Plk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Csk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Cdk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Jnk1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50256750(CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed