BDBM50261129 CHEMBL4064762::US10836758, Example 71

SMILES Fc1cc(NCCC2CCOCC2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=WPCMGHHEOJLHRM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50261129   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50261129(CHEMBL4064762 | US10836758, Example 71)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in baculovirus-infected insect cells using 7-Benzoyloxy-4-trifluoromethyl coumarin substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50261129(CHEMBL4064762 | US10836758, Example 71)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50261129(CHEMBL4064762 | US10836758, Example 71)
Affinity DataIC50:  120nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50261129(CHEMBL4064762 | US10836758, Example 71)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -50 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50261129(CHEMBL4064762 | US10836758, Example 71)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -60 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed